New Data Reveals Decentralized Clinical Trials Yield Better Clinical Trial ROI

In a recent article published by Applied Clinical Trials, CISCRP Founder and Board Chair, Ken Getz, discusses decentralized clinical trials (DCTs) and how their value can be measured. During the pandemic, there became a need for DCTs, and a rapid adoption took place by many CROs. 

“DCT adoption has occurred without the normal phased adoption process that has time to unfold. Because it’s been so rapid, the industry has a lot of questions on how to manage the best DCT moving forward, how to allocate resources, and where to invest,” Ken shares. 

At the recent DIA Annual Meeting in June, Ken presented alongside Pam Tenaerts, MD, Chief Scientific Officer at Medable, providing an overview of their recent work aiming to understand whether DCTs live up to the expectations of better research. Tuft’s CSDD study with Medable on DCTs is the first study quantifying the return on investment of DCTs, an important metric to measure as it can inform decision-making on future projects. 

For this study, Tufts used data from a mixed sample of trials; 150 that used traditional in-person clinical trial methods, and 33 using DCT methodology. This model developed by Tufts and Medable focuses on the value drivers of clinical trials, calculating the overall ROI of a decentralized clinical trial based on value drivers such as cost, trial duration, and execution efficiency. 

The study shows evidence that DCT’s drive speed and efficiency in clinical studies as well as patient recruitment and retention. “Dropout rates appear to be lower in our comparative assessment,” Ken notes. “Second, the screen failure rates improved, and that may be because there is greater decentralized access to a trial. More people who may be eligible are willing to inquire about participating in a study, essentially self-selecting because it appears to be more accessible to join, either because it’s conducted locally or there are more opportunities to participate from home.” 

To read the full article visit Applied Clinical Trials website here: https://www.appliedclinicaltrialsonline.com/view/new-data-reveals-dcts-yield-better-clinical-trial-roi  

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